Estimation of ischemic core in acute ischemic stroke with CT angiography and non-contrast CT: Attenuation changes in ASPECTS regions vs. automated ASPECTS scoring.

For the classification of the infarction extent of ischemic core ≥ 70 ml, the wHU-ASPECTS on NCCT showed the area under the curve (AUC) of 0.891 ( P < 0.001; sensitivity 93.75%, specificity 81.58%), higher than automated NCCT-ASPECTS (AUC = 0.817, P < 0.001; sensitivity 62.5%, specificity 84.21%), with a marginal significance according to DeLong’s test analysis ( P = 0.079); the wHU-ASPECTS based on CTA source images showed the AUC of 0.867 ( P < 0.001; sensitivity 72.22%, specificity 87.8%), higher than automated CTA-ASPECTS (AUC = 0.799, P < 0.001; sensitivity 66.67%, specificity 95.12%), but the difference did not reach statistical significance according to DeLong’s test analysis ( P = 0.373) ( Table 3 and Figure 4 ).

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gnificance according to DeLong’s test analysis ( P = 0.079); the wHU-ASPECTS based on CTA source images showed the AUC of 0.867 ( P < 0.001; sensitivity 72.22%, specificity 87.8%), higher than automated CTA-ASPECTS (AUC = 0.799, P < 0.001; sensitivity 66.67%, specificity 95.12%), but the difference did not reach statistical significance according to DeLong’s test analysis ( P = 0.373) ( Table 3 and Figure 4 ).

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