Single-cell multiomics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection.

Sci Adv · 2022 · PMC9365279 · PMID 35947654

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We found that a series of H3K9me2 methyltransferase G9A (encoded by Ehmt2 ) inhibitors all showed a trend to increase the blastocyst rate of ROSI embryos such as A366 ( 39 ), BIX01294, and BRD4770 ( Fig. 5C ).

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