Inspired by this, we set out to test an important question about the biological significance of cotranslational assembly: do large interfaces give rise to cotranslational assembly because of simple energetic reasons or do they reflect an evolutionary adaptation for a functional benefit? We found a clear trend across three evolutionarily distant species for the first translated interface of heteromeric subunits to be larger, suggesting that large interfaces have evolved to promote cotranslational assembly.
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Large protein complex interfaces have evolved to promote cotranslational assembly.
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