Dual-responsive nanoparticles with transformable shape and reversible charge for amplified chemo-photodynamic therapy of breast cancer.

Acta Pharm Sin B · 2022 · PMC9366228 · PMID 35967278

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Importantly, PEG-His@BPC and PEG-Phe@BPC could accumulate at the tumor site in 48 h, while the fluorescence signal of PEG-His@BRC and PEG-Phe@BRC showed a trend of rapid clearance after 24 h, indicating that shape transformable nanoparticles could be more prone to accumulate at tumor site.

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