Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells.

Cells · 2022 · PMC9368002 · PMID 35954217

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Instead, GPR17-silenced OPCs showed a trend toward altered abundance of free fatty acids, ceramides, acyl-alkyl-phosphatidylcholine (PCae) and phosphatidylinositol (PI) compared to control OPCs, especially at DID 3 and 5, but only diacyl-phosphatidylethanolamine (PEaa) and sphingomyelin (SM) showed a statistically significant change ( Figure 7 ).

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