Toll-like Receptor 7 (TLR7) Is Expressed in Adipocytes and the Pharmacological TLR7 Agonist Imiquimod and Adipocyte-Derived Cell-Free Nucleic Acids (cfDNA) Regulate Adipocyte Function.

No significant correlations were found between the visceral or subcutaneous TLR7 expression and systemic leptin, adiponectin, C1q/TNF-related protein 3 (CTRP3) or CRP levels, while a borderline significant negative correlation was observed between the TLR7 expression and progranulin serum levels (rho = −0.215, p = 0.043 for subcutaneous and rho = −0.202, p = 0.057 for visceral adipose tissue TLR7 expression).

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Remarkably, cfDNA seemed to inhibit Glut4 mRNA expression in a dose-dependent manner in 3T3-L1 adipocytes with borderline significance ( p = 0.056, Figure 4 d).

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Of note, we found a highly significant and strong correlation between the TLR7 and TLR9 gene expression, both in intra-abdominal as well as in subcutaneous adipose tissue compartments in normal-weight mice, indicating a possible interaction between the murine TLR7 and TLR9 gene expression in these compartments.

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The stimulation of the monocyte compartment with imiquimod led to reduced adiponectin and resistin concentrations in the cell-culture supernatants in the adipocyte compartment as well, however, this did not reach statistical significance ( Figure 5 a,b).

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