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Prognostic Impact of the HFA-PEFF Score in Patients with Acute Myocardial Infarction and an Intermediate to High HFA-PEFF Score.

J Clin Med · 2022 · PMC9369752 · PMID 35956205

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In the case of sacubitril/valsartan, although clinical use was authorized by the FDA after further statistical analysis, the primary endpoint of the PARAGON-HF trial, according to the initial design, did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.