Plasma protein profiling reveals dynamic immunomodulatory changes in multiple sclerosis patients during pregnancy.

Indeed, there was a highly significant overlap between the proteins that increased during the 3 rd trimester and decreased post-partum (13/33 proteins, odds ratio (OR): 98.9, p=4.85e-09, Fisher’s exact test, Figure 4B ) and, conversely, between the downregulated proteins during the 3 rd trimester and the ones upregulated post-partum (13/44 proteins, OR: 29.9 , p=1.73e-05, Figure 4C ).

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For the differentially expressed proteins (DEPs), an adjusted p-value<0.05 (Benjamini-Hochberg) was considered statistically significant, unless stated that nominally significant proteins are shown (p-value<0.05).

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