In the TCGA-COAD (HR = 2.54, P < 0.001), TCGA-READ (HR = 2.67, P = 0.026), GSE17536 (HR = 2.30, P < 0.001), GSE17537 (HR = 2.91, P = 0.023), GSE29621 (HR = 3.55, P = 0.004), GSE39582 (HR = 2.37, P < 0.001), GSE72970 (HR = 1.90, P = 0.008), and total CRC cohorts (HR = 2.18, P < 0.001), patients with high CAFDL scores had significant worse OS compared with those with low CAFDL scores ( Figure 3A , Figure S3 ), except for GSE38832 (P = 0.172, HR = 1.79), whose OS difference did not reach statistical significance.
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Development and validation of a cancer-associated fibroblast-derived lncRNA signature for predicting clinical outcomes in colorectal cancer.
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