Genetic Evidence for a Causal Role of Serum Phosphate in Coronary Artery Calcification: The Rotterdam Study.

The analyses in quintiles suggested a threshold for the association of serum phosphate and CAC (Table 4 ): setting the first quintile as reference, men with serum phosphate above 1.09 mmol/L displayed a significant trend for higher CAC (β for fourth quartile, 0.87 [95 CI, 0.46–1.28]; P <0.001; β for fifth quintile, 1.18 [95 CI, 0.77–1.59]; P <0.001; P trend =3×10 −10 ; n=878).

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