CpG content in the Zika virus genome affects infection phenotypes in the adult brain and fetal lymph nodes.

Front Immunol · 2022 · PMC9379343 · PMID 35983032

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showed a trendno p-value reported

Interestingly, some fetuses exposed to recoded Zika virus E+102CpG and particularly E/NS1+176CpG variant showed a trend to higher IFN-γ levels—cytokine critical for immunity against virus infections and eliciting vaccine responses—in comparison to fetuses exposed to the wild-type variant ( Figures 6C , D ); however, a statistically significant difference was not observed (amniotic fluid: p > 0.99; blood plasma: p > 0.99).

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