Firstly, we repeatedly observed interesting trends in our data, which failed to reach statistical significance (e.g., increased substance use and an increase in severe loneliness over time in patients).
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Addiction in the time of COVID-19: Longitudinal course of substance use, psychological distress, and loneliness among a transnational Tyrolean sample with substance use disorders.
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The sentences
Loneliness was a highly significant factor determining the degree of psychological distress, which is consistent with previous publications showing that increased loneliness during the pandemic was associated with an increase in psychological distress or with the intensity of psychopathology ( 41 – 45 ).