Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case-Control Study and Meta-Analysis.

Cancer Epidemiol Biomarkers Prev · 2022 · PMC9381125 · PMID 35086823

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borderline significantno p-value reported

Borderline significant inverse associations with colorectal cancer risk were observed for testosterone (RR per 100 ng/dL = 0.98; 95% CI, 0.96–1.00; I 2 = 22%) and free testosterone (RR per 1 ng/dL = 0.98; 95% CI, 0.95–1.00; I 2 = 0%).

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did not reach statistical significanceno p-value reported

Levels of free testosterone were also inversely associated with colon cancer risk (OR q4-q1 = 0.77; 95% CI, 0.53–1.10; P trend = 0.21; OR per 1-log 2 unit increment = 0.83; 95% CI, 0.58–1.18); however, the association did not reach statistical significance in categorical or continuous analysis.

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