Barely Significant
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.

Nat Commun · 2022 · PMC9381717 · PMID 35974106

Europe PMCDOI
1
hedged sentence
0.0050
closest p · 0.1× alpha
0.0050
boldest claim

The sentences

highly significantp = 0.005actually significant
did not reach statistical significancep = 0.157not close (p > 0.1)
As is evident, aged mouse brain cells (microglia) and regions (prefrontal cortex, dorsal hippocampus) displayed a highly significant enrichment of senescence/SASP genes using the SenMayo gene list ( p = 0.005, p = 0.001, p˂0.001, respectively), while the previously published gene set (R-HSA-2559582) did not reach statistical significance ( p = 0.157, p = 0.117, p = 0.192, respectively).

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