Barely Significant
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Complement C3 inhibition in severe COVID-19 using compstatin AMY-101.

Sci Adv · 2022 · PMC9385148 · PMID 35977025

Europe PMCDOI
1
hedged sentence
0.0970
closest p · 1.9× alpha
0.0970
boldest claim

The sentences

did not reach statistical significanceP = 0.097so close (0.05 < p ≤ 0.1)
On day 14 of the study, a higher proportion of AMY-101–treated patients (13 of 16, 81.3%) than placebo-treated patients (8 of 15, 53.3%) attained resolution of ARDS (PaO 2 /FiO 2 > 300 mmHg) without oxygen requirement in room air; patients attaining resolution were characterized as “responders.” However, the differential response rate between the two groups did not reach statistical significance ( P = 0.097) ( Fig. 1A ).

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