Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer's disease.

Nat Commun · 2022 · PMC9388493 · PMID 35982059

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highly significantP -value = 5.16 × 10 −11actually significant

Our most significant DMR is located on the PM20D1 gene, where highly significant promoter hypomethylation was observed in AD patients ( P -value = 5.16 × 10 −11 , Sidak adjusted P- value = 3.12 × 10 −7 ).

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nominally significantP- value < 0.05actually significant

We then prioritized 97 CpGs and 10 DMRs by requiring these CpGs and DMRs to be also FDR-significant (i.e., FDR < 0.05) in our previous brain sample meta-analysis 5 and at least nominally significant (i.e., P- value < 0.05) in our current blood meta-analysis (Fig. 2 ).

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