Dysregulated insulin secretion is associated with pancreatic β-cell hyperplasia and direct acinar-β-cell trans-differentiation in partially eNOS-deficient mice.

Interestingly, the number of extra‐islet β‐cell clusters (2–5 cells), considered an index of β‐cell neogenesis (Jetton et al., 2005 ), showed a trend to increase in WT HFD and eNOS+/− CF groups, and achieved a significant 2.5‐fold increase in eNOS+/− HFD mice (Figure 3E ).

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