Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells.

In addition, the amount of the released DXd showed a trend of positive correlation with the cell-surface TROP2 level in the cell lines analyzed here (Spearman rank correlation coefficient: ρ = 0.60); however, again there was variation among the cell lines as well ( Fig. 2B ).

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