Heavy caffeine intake with CC genotype reduced PD risk by 47%, while having GRIN2A_rs4998386_T allele with light caffeine intake showed a trend of protectiveness, and the combination of heavy caffeine intake and GRIN2A_rs4998386_TC genotype was associated with an overall 64% PD risk reduction.
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Addressing the Neuroprotective Actions of Coffee in Parkinson's Disease: An Emerging Nutrigenomic Analysis.
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The sentences
However, a borderline significance was reported between the SNP rs11724635 and sporadic PD under the co-dominant and additive models.