Effectiveness of Nootropics in Combination with Cholinesterase Inhibitors on Cognitive Function in Mild-to-Moderate Dementia: A Study Using Real-World Data.

Highly significant between-group differences, in favor of the choline alfoscerate combination and the ginkgo biloba extract combination, were shown in the MMSE language subscale score ( p = 0.001) as well (0.22 for the choline alfoscerate group, 0.26 for the ginkgo biloba group, −0.95 for the other nootropics group) ( Supplementary Table S2 ). 4.

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None of the six-subscale scores showed any significant treatment-by-time interaction, albeit the change in language subscale score showed a trend of less deterioration in the nootropics combination group than in the ChEI only group (−0.27 for the ChEI only group and −0.03 for the ChEI and nootropics combination group; F = 3.43, df = 1581, p = 0.065). 3.3.

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