ROCK inhibition with Y-27632 reduces joint inflammation and damage in serum-induced arthritis model and decreases <i>in vitro</i> osteoclastogenesis in patients with early arthritis.

All the Y-27632 concentrations, from 20 to 100 μM, achieved a highly significant decrease in the number of multinucleated TRAP+ cells compared to the obtained with vehicle ( Figures 5A, B ).

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The first three genes did not show a statistically significant regulation by Y-27632, although showed a trend to a more limited overexpression, although it was non-significant (p = 0.09; p = 0.13; p = 0.07, respectively).

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