Comparison of clinically indicated replacement and routine replacement of peripheral intravenous catheters: A systematic review and meta-analysis of randomized controlled trials.

In subgroup analysis, according to the different schedule (every 72, 72–96, and 96 h) of routine replacement in the control group, the study group had a higher risk of phlebitis than the control group, however, the differences did not reach statistical significance (vs. every 72 h: RR, 1.12; 95% CI, 0.94–1.34, P = 0.20, I 2 = 0%; vs. within 72–96 h: RR, 1.29; 95% CI, 0.85–1.96; P = 0.24; vs. every 96 h: RR, 1.24; 95% CI, 0.79–1.93, P = 0.34, I 2 = 86%) ( Figure 3 ).

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