Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response.

This was accompanied by a highly significant reduction of survival time (p<0.005) following anti-CTLA-4 treatment in mice harboring tumors overexpressing GPX2.

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GPX2 drives shifts in TIME and impacts ICI response In three independent experiments ( figure 5 , online supplemental figure 13 ), tumors grown subcutaneously from MOC1 overexpressing GPX2 in immunocompetent C57BL/6J mice had significantly fewer overall percentage of T cells and decreased percentages of M1-macrophages, with reduced levels of CD8 +T cells significant in 2/3 experiments and trending towards significance in a third replicate experiment.

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