A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced Obesity.

Metabolites · 2022 · PMC9413491 · PMID 36005604

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Acly mRNA levels were significantly downregulated compared to the vehicle control ( p < 0.001) and the pair-fed group ( p < 0.01, Figure S4a ) and Acc1 and Fasn mRNA levels were significantly downregulated compared to the vehicle control ( p < 0.05 and p < 0.01) and showed a trend for reduction compared to the pair-fed group ( p < 0.1 and 0.09, Figure S4b,c ).

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