ERα-Dependent Regulation of Adropin Predicts Sex Differences in Liver Homeostasis during High-Fat Diet.

HFD enhanced Nrf2 mRNA to the levels of females in control males but not LERKO males ( Figure 5 G); conversely, Nrf2 showed a trend to increase in control females (+13%) and a significant induction by HFD in LERKO females (+25%), suggesting that Nrf2 hepatic expression in a setting of excess dietary lipids can be modulated by hepatic estrogen signaling in a sex-specific fashion.

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