At 25 and 75 weeks of age, we observed slight decreases of cleaved caspase-3 expression in cartilage from the BL/6 NZB conplastic mice compared with that from the BL/6 C57 mice at the same ages, but these did not reach statistical significance ( Supplementary Figure 5 ).
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mtDNA variability determines spontaneous joint aging damage in a conplastic mouse model.
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