MRI predictors of pharmacotherapy response in major depressive disorder.

Two studies failed to find an association between remission status and changes in hippocampal volume: one twelve week trial in LLD did, however, report nearly significant increases in hippocampal volume for remitters and decreases for non-remitters ( Khalaf et al., 2015 ) and one year-long trial in mid-life ( Frodl, 2004 ).

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