Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.

J Med Chem · 2022 · PMC9421654 · PMID 35972896

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The series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amine compounds showed a trend of reducing overall adult worm burden in the L. sigmodontis mouse and jird infection model.

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