Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.

Additionally, significant associations with ADL disability were also observed for manganese, copper, and arsenic when other metals set at their 25th, 50th, and 75th percentile, though the association of cadmium was approaching significance ( p- values: 0.50 and 0.53) when other metals set at their 50th and 75th percentile ( Figure 1B and Excel Table S2).

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