Targeting SIRT1 Rescues Age- and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels.

22 , 45 SRT2104 showed a trend in improving the estimated mitochondrial oxidative capacity in humans. 46 However, evidence is poor, and both resveratrol and SRT1720 partially fail to achieve cardiometabolic relevant effect due to their demonstrated lack of vascular selectivity, instead exhibiting an organ preference for liver and white adipose tissue. 47 Here, we report for the first time a direct effect of SRT1720 on the human microcirculatory function, accurately measured through a complex ex vivo setting.

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