Flow cytometry analysis of tumor samples showed a trend toward a decline in M2 macrophage infiltration and an increase in M1 macrophage infiltration ( Figure 3a,b ), accounting for an average two-fold increase in the M1/M2 ratio (p = 0.056; Figure 3c ).
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CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment.
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