Modulation of dendritic cell metabolism by an MPLA-adjuvanted allergen product for specific immunotherapy.

Front Immunol · 2022 · PMC9430023 · PMID 36059475

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did not reach statistical significanceno p-value reported

Interestingly, IL-1β secretion was increased upon inhibition of amino acid metabolism by BPTES, which however did not reach statistical significance ( Figure 5D ) due to intra-experimental variations.

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highly significantno p-value reported

Moreover, AIT product 1 induced a dose-dependent and, for higher stimulation concentrations, highly significant secretion of the cytokines IL-1ß, IL-10, and TNF-α ( Repository Figure E3A ).

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