Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.

J Clin Invest · 2022 · PMC9433107 · PMID 35852856

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Consistently, the increased H3K27ac peaks in the PRC2/H3K27me3 loss context showed a trend toward closer distances to the nearest H3K27me3 peaks compared with the decreased H3K27ac peaks, while their distances to H3K36me3 peaks were reversed ( Supplemental Figure 2J ).

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