Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

Among 334 participants aged less than 45 years (mean 33 years)– 163 with a polygenic score in the bottom decile versus 171 in the top decile–we note directionally consistent and nominally significant results (p <0.05 in a logistic model that included age, sex and the first four principal components of ancestry) for 25 out 28 proteins identified in the overall cohort ( S4 Fig ).

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