Orexin 2 receptor-selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients.

Proc Natl Acad Sci U S A · 2022 · PMC9436334 · PMID 35994639

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Finally, in humans, OX2R polymorphisms affect morningness–eveningness, napping, and reports of excessive daytime sleepiness, while OX1R polymorphisms have smaller but nominally significant effects on sleepiness and napping, based on numerous studies and data in the Sleep Disorder Knowledge Portal ( https://sleep.hugeamp.org/ ) ( 40 – 43 ).

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