Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca²⁺ Overload.

Although heart weight normalized to tibial length failed to reach statistical significance in HFD groups ( Figure 3G ), Parkin ablation accentuated HFD intake–provoked rises in cardiomyocyte cross-sectional area, intracardial accumulation of lipids, and interstitial fibrosis ( Figures 3H to 3M ).

also in 6,035 other papers