Depression is differentially related to cognitive and biomarker outcomes among Mexican Americans.

Front Psychiatry · 2022 · PMC9445986 · PMID 36081458

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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a trend toward significancep = 0.05actually significant

Among Mexican Americans, GDS scores were significantly associated with the frontal amyloid burden ( t = -2.01, p = 0.04) with a trend toward significance among anterior/posterior cingulate ( t = -2.02, p = 0.05) and global amyloid burden ( t = -1.83, p = 0.08).

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approaching significancep = 0.08so close (0.05 < p ≤ 0.1)

Among APOE ε4 non-carrier Mexican Americans, GDS scores were associated with poorer performance in the areas of processing speed (Trails A t = 2.73, p = 0.007, SDMT t = -3.47, p < 0.001), executive functioning (Trails B t = 2.09, p = 0.04), language (FAS t = -3.82, p < 0.001) as well as immediate (WMS-III LM1 t = -2.07, p = 0.04; SEVLT 1-5 t = -4.03, p < 0.001) and delayed (SEVLT Delayed t = -2.84, p = 0.005 with WMS-III LM2 t = -1.76, p = 0.08 approaching significance).

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