Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model.

In the static rod task, apoe/fas double knockout mice treated with resveratrol showed a trend towards walking across the 9 mm rod faster (traverse time: 83.03 ± 12.07 s) compared to apoe/fas control mice (traverse time: 114.88 ± 5.13 s) and apoe/fas mice treated with resveratrol and istradefylline (traverse time: 114.75 ± 5.25 s; F(2,17) = 3.053, p = 0.07; Fig. 2 B).

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