Immunomodulatory effects of metronomic vinorelbine (mVRL), with or without metronomic capecitabine (mCAPE), in hormone receptor positive (HR+)/HER2-negative metastatic breast cancer (MBC) patients: final results of the exploratory phase 2 Victor-5 study.

BMC Cancer · 2022 · PMC9446532 · PMID 36068484

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep -value = 0.09so close (0.05 < p ≤ 0.1)

At the same time, the TregACT/Treg ratio showed a significant increase between T0 and T4 and the Treg Naive / Treg ratio shows a clear increasing trend, even if it did not reach statistical significance (T0/T3 p -value = 0.09).

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