Neural correlates found to be implicated in HSD are similar to those reported in the above-mentioned psychiatric disturbances, especially in the field of anxiety, alexithymia, and interoception abnormalities: Eccles et al., in a neuroimaging study ( 27 ) have found that bilateral amygdala volume was significantly greater in a group of hypermobile patient compared to a group of non-hypermobile individuals; additionally, the same hypermobility group scored higher for interoceptive sensitivity, suggesting a more finely tuned sensory representation of internal bodily signals, and showed a trend toward significantly higher levels of anxiety.
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Hypermobile spectrum disorders symptoms in patients with functional neurological disorders and autism spectrum disorders: A preliminary study.
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