Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant.

Proportions of HIV-viremic PWH who had quantifiable neutralization, defined as titers above LOQ at the time point 1 month after diagnosis, trended lower relative to HIV-suppressed PWH and HIV-negative participants for all 3 variants ( Figure 2 F –2 H ); this difference had borderline significance for Delta (had neutralization above LOQ, 56% of HIV-negative participants vs 86% of suppressed and 27% of viremic PWH; P = .049 [χ 2 test]).

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Relative to HIV-negative and HIV-suppressed participants, those who were HIV viremic showed a trend toward lower neutralization of the ancestral strain ( Figure 2 C ), the Beta variant ( Figure 2 D ), and the Delta variant ( Figure 2 E ); this was significant for the Beta variant.

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