Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models.

Life Sci Alliance · 2022 · PMC9458754 · PMID 36271507

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showed a trendno p-value reported

Moreover, intratumoral IFNγ levels were significantly increased in DuoBody-CD3x5T4 treated animals, whereas intratumoral IL-6, IL-8, and TNFα levels showed a trend of increase that was not statistically significant when compared with IgG1-ctrl-treated tumors ( Fig 6G ).

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