Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria.

5e ) but although there was a trend of increased cholesterol levels with Mtb lipid treatment, it did not reach statistical significance for any of the strains (Fig. 5f ).

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smegmatis , the non-pathogenic model organism did not achieve significance and M. canettii diminished reduced LysoTrackerTM staining relative to control cells (Fig. 1a ).

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