Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes.

Nat Commun · 2022 · PMC9464252 · PMID 36088354

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

nominally significantp < 0.1so close (0.05 < p ≤ 0.1)

Additionally, in cases where either missense-variant score test used in the sLRT was nominally significant ( p < 0.1), we combined missense and protein LOF variants for joint tests.

also in 7,732 other papers

highly significantno p-value reported

We therefore hypothesized that the other highly significant variants could also potentially be gain of function variants.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.