Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.

Results suggest directly positive and indirectly negative (via CRP) associations of the SNP with BMI, though total effect (e.g., direct + indirect effect) was positive but marginally nonsignificant (beta = 0.12, 95% CI [− 0.01, 0.26]) (Table 3 ).

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We considered a SNP as a candidate for pleiotropy analyses if a): exceeded significance threshold for multi-trait test at PaSPU < 1.25 × 10 –8 , a conservative threshold [ 47 ] which accounted for multiple testing on likely low frequency SNPs and the number of traits tested, and b) nominally significant for inflammation and at least one adiposity trait in univariate GWAS results.

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