Sodium-glucose cotransporter 2 (SGLT2) inhibitor initiation and hepatocellular carcinoma prognosis.

In sensitivity analysis 3 that employed the propensity score approach and further matched distance between HCC diagnosis and initiation of the two compared drugs, SGLT2 inhibitor use was not statistically significant and long duration of SGLT2 inhibitor use was only borderline significant ( Table 3 ).

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We further examined the association between SGLT2 inhibitor use and risk of mortality stratified by different covariates and found that SGLT2 inhibitor use was associated with a reduced risk of mortality regardless of patients’ demographic, tumor characteristics and cancer treatments, although some results did not reach statistical significance due to small sample sizes in some of the sub-groups ( Fig 2 ).

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