Repeated stress exposure leads to structural synaptic instability prior to disorganization of hippocampal coding and impairments in learning.

2l ) with the difference between control and stress groups becoming highly significant only after 5 days of repeated stress (Supplementary Fig. 5g ).

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However–owing to high baseline levels–stress-induced increase in circulating corticosterone did not reach statistical significance over baseline (Supplementary Fig. 3a–c ).

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