Loss of Fas Receptor Function Preserves Photoreceptor Structure and Function in Two Mouse Models of Inherited Retinal Degeneration.

Invest Ophthalmol Vis Sci · 2022 · PMC9469031 · PMID 36083588

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did not reach statistical significanceno p-value reported

Although the reduction in interleukin (IL)-1β and tumor necrosis factor (TNF)-alpha did not reach statistical significance in the P23H/Fas-lpr mouse, it did in the rd10/Fas-lpr mouse.

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may be significantno p-value reported

Even if incomplete, the rescue afforded by reducing Fas activity may be significant to a patient suffering from one of these degenerations and further work should be conducted to explore this potential.

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