Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm.

Nat Commun · 2022 · PMC9470591 · PMID 36100613

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While loss of IL-1β restricted to hematopoietic cells showed a trend towards increased levels of IL-1Ra in BM, this trend was not observed in mice with complete loss of IL-1β in all tissues (Supplementary Fig. 7c ), suggesting that the overall activity of IL-1 signaling is reduced when IL-1β is lost in hematopoietic cells only.

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