Effect of uniform capacitively coupled electric fields on matrix metabolism of osteoarthritic cartilage.

Although the application of IL-1B and CCEFs to rabbit hyaline chondrocytes did not yield statistically significant differences in gene expression, there is a clear trend showing that treatment with IL-1B resulted in elevated expression of inflammatory markers and decreased expression of matrix components while simultaneous treatment with IL-1B and CCEFs resulted in a relative decrease in expression of inflammatory markers and increase in expression of matrix components.

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Brighton and coauthors applied IL-1B and CCEF stimulation to bovine articular cartilage explants for one week and showed highly significant increases in Aggrecan and Collagen-2 expression in the explants stimulated by CCEFs both in the absence and presence of IL-1B (Brighton et al. 2006 ).

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